Everything You Need to Know About Citalopram (Celexa)
Citalopram, commonly known by its brand name Celexa, is a widely prescribed antidepressant that can help improve mood, reduce anxiety, and manage obsessive thoughts. If you’re considering citalopram or just want to learn more about it, this guide breaks it down in simple, easy-to-understand terms.
What is Citalopram?
Citalopram is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the levels of serotonin—a key brain chemical that regulates mood, sleep, and emotions. By blocking serotonin from being reabsorbed too quickly, citalopram helps keep more serotonin available in your brain, which can improve symptoms of depression and anxiety.
What is Citalopram Used For?
Citalopram is FDA-approved to treat:
- Major depressive disorder (depression).
- Anxiety disorders.
It’s also prescribed off-label for:
- Obsessive-compulsive disorder (OCD).
- Panic disorder.
- Post-stroke depression.
- Depression in patients with chronic illnesses (e.g., heart disease, kidney failure, or HIV).
Who Should Avoid Citalopram?
Citalopram isn’t for everyone. Talk to your doctor if you:
- Are allergic to citalopram or other SSRIs.
- Take MAOIs (another type of antidepressant) or have recently stopped them (wait 2 weeks).
- Have a history of heart problems, especially abnormal heart rhythms (e.g., QT prolongation).
- Are pregnant or breastfeeding (discuss risks vs. benefits with your doctor).
What Are the Side Effects?
Common side effects (usually mild and temporary):
- Nausea, upset stomach.
- Dry mouth.
- Drowsiness or insomnia.
- Sweating.
- Headache.
Rare but serious side effects:
- QT prolongation (a heart rhythm issue, especially at doses above 40 mg/day).
- Serotonin syndrome (agitation, rapid heartbeat, high fever—seek help immediately).
- Hyponatremia (low sodium levels, more common in older adults).
- Bleeding or bruising (if taking blood thinners or NSAIDs).
Precautions to Keep in Mind
- Start low, go slow: Your doctor may start you at 10–20 mg daily and increase gradually.
- Watch your heart: Avoid doses above 40 mg/day unless closely monitored by your doctor.
- Monitor your mood: Especially in the first weeks, report any worsening depression or suicidal thoughts.
- Avoid alcohol: It can worsen drowsiness or dizziness.
- Liver/kidney issues? You may need a lower dose.
Drug Interactions to Avoid
Citalopram can interact with other medications. Always tell your doctor if you’re taking:
- MAOIs: Can cause serotonin syndrome.
- Blood thinners (e.g., warfarin): Increased bleeding risk.
- NSAIDs (e.g., ibuprofen): May reduce citalopram’s effectiveness and increase bleeding risk.
- CYP2C19 inhibitors (e.g., cimetidine): Can increase citalopram levels and risk of side effects.
- Thioridazine or pimozide: Can cause dangerous heart rhythms.
How to Take Citalopram
- Dosage:
- Depression and anxiety: Start with 10–20 mg daily, increasing to a maximum of 40 mg/day.
- OCD: Higher doses (up to 80 mg/day) may be used under close supervision.
- Forms: Tablets (scored for easy splitting) and liquid solution.
- Tips: Take once daily, with or without food. Avoid crushing or chewing tablets.
Who Makes Citalopram?
The brand-name version Celexa is manufactured by Lundbeck. Generic versions are also widely available and equally effective.
Final Thoughts
Citalopram can be a helpful tool for managing depression and anxiety, but it’s not a one-size-fits-all solution. Work closely with your doctor to find the right dose and monitor for side effects. And remember—it may take 4–6 weeks to feel the full benefits. Stay patient, stay informed, and prioritize your mental health!
Disclaimer: This article is for informational purposes only. Always consult your healthcare provider before starting, stopping, or changing medications.
