Everything You Need to Know About Fluoxetine (Prozac)
If you’ve ever heard of Prozac, you’re already familiar with fluoxetine. But what exactly is it, how does it work, and what should you know before taking it? Let’s break it down in simple terms so you can understand how this medication might help you or someone you care about.
What is Fluoxetine?
Fluoxetine is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It’s commonly prescribed to help balance serotonin levels in your brain. Serotonin is a chemical that plays a key role in regulating mood, sleep, and appetite. By boosting serotonin, fluoxetine can help improve symptoms of depression, anxiety, and other mental health conditions.
What is Fluoxetine Used For?
Fluoxetine is FDA-approved to treat a variety of conditions, including:
- Major depressive disorder (for ages 8 and older)
- Obsessive-compulsive disorder (OCD)
- Bulimia nervosa (an eating disorder)
- Panic disorder
- Premenstrual dysphoric disorder (PMDD) (a severe form of PMS)
- Posttraumatic stress disorder (PTSD)
It’s also used off-label (not officially approved but commonly prescribed) for conditions like:
- Anxiety disorders
- Chronic pain
- Borderline personality disorder
- Bipolar disorder (when combined with other medications)
Who Should Avoid Fluoxetine?
Fluoxetine isn’t for everyone. You should avoid it or use it with caution if:

- You’re allergic to fluoxetine or any of its ingredients.
- You’re taking or have recently taken a monoamine oxidase inhibitor (MAOI) (a type of antidepressant). Combining these can lead to a dangerous condition called serotonin syndrome.
- You have a history of seizures, bipolar disorder, or liver/kidney problems.
- You’re pregnant or breastfeeding (talk to your doctor first, as fluoxetine can pass to the baby).
What Are the Side Effects of Fluoxetine?
Like all medications, fluoxetine can cause side effects. Some common ones include:
- Nausea
- Headache
- Trouble sleeping
- Dry mouth
- Fatigue
- Dizziness
More serious but rare side effects include:
- Suicidal thoughts (especially in young people under 25)
- Serotonin syndrome (symptoms include confusion, rapid heart rate, and high fever)
- Hyponatremia (low sodium levels, more common in older adults)
- QT prolongation (a heart rhythm issue)
If you experience any severe side effects, contact your doctor immediately.
Precautions When Taking Fluoxetine
Here are some important things to keep in mind:
- Start low, go slow: Your doctor will likely start you on a low dose and gradually increase it to minimize side effects.
- Monitor your mood: Especially in the first few weeks, watch for changes in mood, behavior, or suicidal thoughts.
- Avoid alcohol: It can worsen side effects like drowsiness and dizziness.
- Be patient: It can take 4–6 weeks to feel the full benefits of fluoxetine.
Drug Interactions to Watch Out For
Fluoxetine can interact with other medications, so always tell your doctor about everything you’re taking. Key interactions include:
- MAOIs: Can cause serotonin syndrome.
- Tramadol: Increases the risk of seizures.
- Blood thinners (like warfarin): Fluoxetine can increase bleeding risk.
- Other antidepressants: Combining SSRIs can increase side effects.
How to Take Fluoxetine
- Dosage: The typical dose ranges from 20–80 mg per day, depending on your condition. For bulimia, the dose is usually higher (60–80 mg).
- When to take it: Take it once a day, usually in the morning. If it makes you feel nauseous, try taking it with food.
- Forms available: Fluoxetine comes in capsules, tablets, and liquid form. There’s also a weekly capsule (90 mg) for maintenance.
Who Makes Fluoxetine?
Fluoxetine is sold under the brand name Prozac, which is manufactured by Eli Lilly and Company. It’s also available as a generic drug, which is made by various pharmaceutical companies.
Final Thoughts
Fluoxetine can be a life-changing medication for many people struggling with depression, anxiety, or other mental health conditions. However, it’s not a one-size-fits-all solution. Always work closely with your doctor to find the right treatment plan for you. If you’re considering fluoxetine, don’t hesitate to ask questions and share any concerns—your mental health is worth it!
Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting or stopping any medication.